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pentobarbital will reduce the level or impact of pazopanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will reduce the level or influence of imatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.pentobarbital will lessen the level or impact of amlod